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Women are Dying Early Because of no Hormone Replacement Therapy? A study from Yale University School of Medicine

Women are Dying Early Because of no Hormone Replacement Therapy?    A study from Yale University School of Medicine
Could something good possibly have come from the flawed Women’s Health Initiative study?  When the WHI was halted in July 2002 due to early results showing an increase in stroke and heart disease, the media hype frightened doctors and patients alike.  The result: abrupt discontinuation of Hormone Replacement Therapy, or HRT, all over the country.
Sadly, peri and post menopausal women went right back to their hot flashes, vaginal dryness, mental fog, and other debilitating symptoms. 
 Now we have a new problem in medicine:  Estrogen Avoidance
Since the mass exodus from Estrogen Therapy after 2002 many women are at risk for dying early.  It is apparent now that we need estrogen to keep our hearts, arteries and bones healthy.  The WHI study was flawed.  The wrong hormones were used–they were not bioidentical and led to side effects.  
Look at the abstract below.  This data from Yale translates easily to nearly all peri and postmenopausal women, not just those with a history of hysterectomy.  
Have a discussion with your doctor right away.  It is “a matter of considerable urgency.”  Protect yourself from an early death.  Bio-identical HRT properly prescribed and followed will improve your health and your wellbeing.


Am J Public Health. 2013 Sep;103(9):1583-8. doi: 10.2105/AJPH.2013.301295. Epub 2013 Jul 18.

The mortality toll of estrogen avoidance: an analysis of excess deaths among hysterectomized women aged 50 to 59 years.

Sarrel PM1, Njike VYVinante VKatz DL.

Author information

  • 1Departments of Obstetrics and Gynecology and Psychiatry, Yale University School of Medicine, New Haven, CT, USA.



We examined the effect of estrogen avoidance on mortality rates among hysterectomized women aged 50 to 59 years.


We derived a formula to relate the excess mortality among hysterectomized women aged 50 to 59 years assigned to placebo in the Women’s Health Initiative randomized controlled trial to the entire population of comparable women in the United States, incorporating the decline in estrogen use observed between 2002 and 2011.


Over a 10-year span, starting in 2002, a minimum of 18 601 and as many as 91 610 postmenopausal women died prematurely because of the avoidance of estrogen therapy (ET).


ET in younger postmenopausal women is associated with a decisive reduction in all-cause mortality, but estrogen use in this population is low and continuing to fall. Our data indicate an associated annual mortality toll in the thousands of women aged 50 to 59 years. Informed discussion between these women and their health care providers about the effects of ET is a matter of considerable urgency.


At medAge, we help patients achieve optimal health, including bioidentical HRT.  Call for a free phone consultation.  We are here to help you.


To Your Optimal Health!  Dr. Laura


Orange Glasses Might Help You Sleep Better?

Orange Glasses Might Help You Sleep Better?

Sleep is critical for optimal health.  It allows our cells to “restore” themselves.  Scientific studies show most adults need at least 7 hours of restful sleep to stay healthy and be in top cognitive and physical shape.  And catching up on the weekends just doesn’t cut it.

So why is it so hard for many of us to fall and/or stay asleep?  There are many potential causes of insomnia. Stress, illness, a new baby, a snoring partner, alcohol consumption, hormone imbalances…but one common problem that is becoming more widespread is melatonin deficiency.  Melatonin is a natural hormone secreted by the pineal gland and other tissues in the brain. Levels of melatonin are 10-15x higher at night than day in all organisms, from bacteria to humans. In sufficient amounts it helps us fall asleep.  It’s production decreases with age and with exposure to light, especially from the blue part of the spectrum.

“Devices such as smartphones and tablets are often illuminated by light-emitting diodes, or LEDs, that tend to emit more blue light than incandescent products. Televisions with LED backlighting are another source of blue light… said Debra Skene, a professor of neuroendocrinology at the University of Surrey in England.

A Swiss study of 13 teenage boys, published in August in The Journal of Adolescent Health, showed that when the boys donned orange-tinted glasses, also known as blue blockers and shown to prevent melatonin suppression, in the evening for a week, they felt “significantly more sleepy” than when they wore clear glasses. The boys looked at their screens, as teenagers tend to do, for at least a few hours on average before going to bed, and were monitored in the lab.

LEDs are also increasingly popular as room lights, but “warm white” bulbs, with less blue, tend to be a better choice than “cool white” for nighttime use. The lighting company Philips also makes a bulb, called Hue, that can change the intensity of its component colors via an app, and GE last month announced a reduced-blue LED bulb, meant to be used before bedtime.”  Kate Galbraith, writer for The New York Times, April 7, 2015

Why is all of this so important?  Melatonin is the most effective free radical scavenger known. Essentially, it acts as a potent antioxidant.

  • It protects DNA and proteins from injury
  • It protects mitochondria
  • It protects against ionizing radiation
  • It enhances immune function
  • It inhibits tumor growth
  • It improves recovery after exercise
  • It helps initiate and maintain sleep at night

Low melatonin is associated with:

  • Alzheimer’s disease
  • Cardiovascular disease
  • Insulin resistance (which can lead to diabetes)
  • Cancer
  • Infectious disease
  • Immune dysfunction

My recommendations:
1.  Turn off LED emitting devices 1 1/2 hours before bedtime.  Don orange tinted glasses if you must check email or surf the web late at night.  My teenage sons use their laptops for homework until the wee hours many nights–perfect candidates for the blue light blocking orange shades. click here for orange lens glasses

2.  Supplemental melatonin:  take ½ hour before sleep.  As little as 0.3mg by mouth may be enough for some people.  Increase dose in increments up to 3-30mg.  If unpleasant dreams occur reduce dose to previous effective dose.

Melatonin-CR_90c-072512I take 9mg of Xymogen brand melatonin.  I buy the 3mg tab and take 3 of them every night.

Learn more about how Dr. Wiltse, Trina Pistor and medAge® can help you improve your health and function and feel better everyday!

To Your Optimal Health!  Dr. Laura

Herrera J et al.  Melatonin prevents oxidative stress resulting from iron and erythropoietin administration. Am J Kidney Dis 2001 Apr;37(4):750-7

Reiter RJ et al. Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage. Pol J Pharmacol. 2004 Mar-Apr;56(2):159-70.

Nelson RJ Melatonin mediates seasonal changes in immune function Ann N Y Acad Sci 2009;917:404-15

Kriegsfeld LJ In vitro melatonin treatment enhances cell-mediated immune function in male prairie voles J Pineal Res 2001 May;30(4):193-8

Carrillo-Vico A et al. Melatonin: buffering the immune system. Int J Mol Sci. 2013 Apr 22;14(4):8638-83

Piepaoli W, Regelson W. Pineal control of aging:effect of melatonin and pineal grafting on aging mice. Proc Natl Acad Sci USA 1994;91:787-91

Carretero, M et al. Long-term melatonin administration protects brain mitochondria from aging. J of Pineal Res, 47(2):192-200, Sept 2009

Ochoa JJ et al. Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. J Pineal Res. 2011 Apr 21

Mills E et al. Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis.  J of Pineal Res. 39(4);360-366, Nov 2005

Escames, G et al. The role of mitochondria in brain aging and the effects of melatonin. Current Neuropharmacology, 2010, 8, 182-193

Jie Fu et al. Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro. J Pin Res Feb 1, 2011

Reiter R et al. The disaster in Japan:utility of melatonin in providing protection against ionizing radiation. J Pin Res. 2011 May;50(4):357-8.

Kostoglou-Athanassiou I. Therapeutic applications of melatonin. Ther Adv Endocrinol Metab. 2013 Feb;4(1):13-24


medAge and Championship Motorcycle Racers Join Taste of Speed in Support of Bert’s Big Adventure

2014 Taste of Speed fashion runway.

This weekend the 2015 Taste of Speed™ Jet Port Experience will be held at PDK Airport at the Jet Linx – Signature Flight Support hangar. The 12,600 square feet hangar will be transformed into a lavishly decorated venue featuring exotic cars, private jets and medAge supported race motorcycles. Guests will enjoy amazing food by regional chefs and signature cocktails while being entertained by live music, Ariel Cirque Performers and a top model fashion show.  All to support Bert’s Big Adventure.


Bert’s Big Adventure is a 501(c)(3) nonprofit organization that provides a magical, all-expenses-paid, five-day journey to Walt Disney World® for children with chronic and terminal illnesses and their families.

Join me, and Champion Racers Jackson Blackmon, Chuck Blackmon, Seth Starnes and Scott Carpenter for an enjoyable evening and a great cause. For tickets click here:  VIP Tickets

To Your Optimal Health!  Dr Laura

13 year old Champion Jackson Blackmon on his Moriwaki 250

Veteran AMA Champion and 2105 Daytona Heavy Weight Superbike winner Seth Starnes


Low Carb vs. Low Calorie Diets. A Study in the American Journal of Clinical Nutrtion

Low Carb vs. Low Calorie Diets.  A Study in the American Journal of Clinical Nutrtion

A Study in the American Journal of Clinical Nutrition

Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction.

This study set out to determine the effectiveness of low carbohydrate vs low calorie diets in weight loss and specifically in fatty liver reduction.  Subjects with NAFLD (Non Alcoholic Fatty Liver Disease) frequently associated with typical American obesity, were placed on a 2 week diet of either reduced carbs (sugars, breads, pastas, white potatoes) or a calorie restricted diet.

Both groups lost weight.  However, the the low carb group lost more weight AND had a reduction in liver fat.

This is very important because liver fat is dangerous leading not only to obesity but also to diabetes, high blood pressure and heart disease.  Often this is referred to as Metabolic Syndrome–a growing problem world wide.  In fact, we are seeing this condition in very young children and for the first time in medical history the current youngest generation is expected to have a SHORTER lifespan than their parents and grandparents.


Stem Cell Therapy for the Joints and Skin

Thank you to all of you who attended the January 20th Stem Cell Seminar at the Hilton in Biltmore Park.  Dr Eglinton of Asheville Biologics & Orthopaedics, Drs Whalen and Mogannam of Flexogenix and I described how Regenerative Medicine using Pure PRP and Stem Cells is improving the lives of patients with joint pain and osteoarthritis.
Thank you also to Mary Koppenheffer and The Biltmore Beacon for excellent news coverage.  One note: Stem cells used are not of embryonic origin.

Drs Eglinton, Ellis, Mogannam and Whalen.  Photo:Mary Koppenheffer

Many attendees have asked to see the video of this event.

Click here to access the Stem Cell Seminar on YouTube.

Stem Cell Therapy is widely used around the world for many medical and orthopedic conditions.  Last year, hundreds of NFL players underwent successful stem cell treatments for injuries.

Peyton Manning had stem cell therapy to help heal a neck injury

Learn more about this cutting edge medicine by clicking on the links above or visiting Dr Eglinton in Western North Carolina or Flexogenix in Cary, NC or Los Angeles, CA.  Come visit me at my office in Asheville to discuss how stem cells rejuvenate the skin of the face, neck, chest, anywhere you have aging skin!

Pure PRP and stem cells rejuvenate skin

To Your Optimal Health!

 Dr. Laura


The Pardon, a must-see film

I’m a film buff and this one has everything I love in a great production.  Amazing acting, real-life drama and a message worth hearing.

The Pardon is a 2013 film produced and directed by Tom and Sandi Anton.  In it Jaime King plays Toni Jo Henry, a product of childhood abuse and neglect, who briefly discovers love and happiness.  While awaiting execution in a Louisiana prison for murder (not really known if she was truly guilty of this crime), Toni Jo meets Father Richard and learns that she is Pardoned in God’s eyes. 

Filmed in Shreveport, Louisiana, it stars the incredible actor John Hawkes as “Arkie” Burke, Henry’s partner in the crime.

Jaime King and John Hawkes as Toni Jo Henry and “Arkie” Burke discuss how to get her fiance out of jail

The film will be screened along with the Anton’s film Anything for Love on Tuesday January 13th at 7pm at Grace Centre, 495 Cardinal Rd. Mills River, NC (just West of Asheville Airport).  $10 at the door and worth every penny!  The Producers will be in attendance for a Q&A after the films.  Please join me!

Go here for more information on the WNC Film Society

See you at the movies,  Dr. Laura


Pure PRP and Stem Cell Treatments for the Ultimate in Skin Rejuvenation

We’ve practiced cutting edge medicine for over 10 years so it’s no surprise that we offer the best skin rejuvenation procedures available.   Fractionated CO2 Laser Resurfacing continues to be the gold standard for improving skin elasticity and removing wrinkles.  Now, with the NEW Pure PRP® system we are performing state-of-the-art Platelet Rich Plasma and Stem Cell treatments too.  This new technology allows us to achieve superior benefits, providing high concentrations of platelet & growth factors in a pure plasma suspension without red blood cells.  Less sophisticated systems allow contamination of red blood cells in the PRP which has been reported to cause pain and subsequent inflammation.  Use of Pure PRP cuts the healing time of Laser Skin Resurfacing nearly in half and promotes significantly more collagen growth and visible results.  Pure PRP Treatment alone requires no significant downtime.  You’re back to work or usual activities the next day!

Call now to schedule a FREE consultation in January 2015


To Your Optimal Health!  Dr Laura