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Unlike traditional fillers that simply add volume, biostimulators work by triggering your body's own collagen production — delivering results that improve over time and last significantly longer. Radiesse and Sculptra are the two FDA-approved biostimulators available at medAge.
Volume loss is the primary driver of facial aging — but there are two fundamentally different approaches to addressing it. Traditional HA fillers add volume directly through the filler itself. Biostimulators go a step further, triggering the body to produce new collagen in the treated areas — so the benefit compounds over time rather than simply filling a deficit.
Hyaluronic acid fillers add volume by placing a gel substance beneath the skin. Results are immediate and reversible. The volume exists as long as the filler exists — typically 6–12 months — then gradually metabolizes. No new collagen is produced.
Biostimulators (Radiesse and Sculptra) trigger the body's own fibroblasts to produce new collagen in the treated area. Results are gradual and build over weeks to months. Because you're building real tissue, results last significantly longer — up to 2+ years in many cases — and continue improving after treatment.
Radiesse provides immediate volume through its CaHA gel carrier, then stimulates collagen production as the microspheres are gradually absorbed. It does double duty — immediate lift and structure, followed by long-term collagen support. FDA-approved for nasolabial folds, facial wrinkles and folds, hand augmentation, and jawline contour (Radiesse+). Best for structural areas requiring immediate lift alongside longer-term collagen support.
Learn about Radiesse →Sculptra works exclusively as a collagen stimulator — there is no immediate volume from the product itself. Instead, Sculptra's PLLA microparticles trigger a sustained collagen-building response over a series of treatments, producing gradual volumization that looks completely natural because it is your own tissue. Results build over 3–6 months and can last 2+ years. FDA-approved for deep nasolabial folds and facial wrinkles. Best for patients who want subtle, progressive restoration with very long-lasting results.
Learn about Sculptra →You want longer-lasting results with less frequent maintenance
You prefer gradual, natural-looking improvement rather than immediate volume
You're concerned about overall skin quality and collagen depletion, not just specific lines
You want volume that genuinely looks like your own face — not added filler
Structural support and collagen foundation are the primary goal
You want immediate, visible results from the first appointment
You want the option to dissolve the filler if you change your mind
The treatment area is delicate or superficial (lips, under-eye, perioral lines)
A specific event or deadline is driving your timeline
You're exploring fillers for the first time and want a lower-commitment option
Many patients use biostimulators and HA fillers together — biostimulators for long-term collagen foundation, HA fillers for targeted precision in delicate areas. Your injector will discuss the right approach for your anatomy and goals at your consultation.
Book a consultation at medAge. We'll assess your anatomy and goals — and recommend whether Radiesse, Sculptra, an HA filler, or a combination is the right approach for your specific situation.
$75 new patient deposit · applied toward your first treatment
Financing available through PatientFi — pay as low as $97/mo. See payment options →